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The Mitochondrial Disulfide Relay System : Roles in Oxidative Protein Folding and Beyond
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Disulfide bond formation drives protein import of most proteins of the mitochondrial intermembrane space (IMS).
The main components of this disulfide relay machinery are the oxidoreductase Mia40 and the sulfhydryl oxidase Erv1/ALR.
Their precise functions have been elucidated in molecular detail for the yeast and human enzymes in vitro and in intact cells.
However, we still lack knowledge on how Mia40 and Erv1/ALR impact cellular and organism physiology and whether they have functions beyond their role in disulfide bond formation.
Here we summarize the principles of oxidation-dependent protein import mediated by the mitochondrial disulfide relay.
We proceed by discussing recently described functions of Mia40 in the hypoxia response and of ALR in influencing mitochondrial morphology and its importance for tissue development and embryogenesis.
We also include a discussion of the still mysterious function of Erv1/ALR in liver regeneration.
American Psychological Association (APA)
Fischer, Manuel& Riemer, Jan. 2013. The Mitochondrial Disulfide Relay System : Roles in Oxidative Protein Folding and Beyond. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-495188
Modern Language Association (MLA)
Fischer, Manuel& Riemer, Jan. The Mitochondrial Disulfide Relay System : Roles in Oxidative Protein Folding and Beyond. International Journal of Cell Biology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-495188
American Medical Association (AMA)
Fischer, Manuel& Riemer, Jan. The Mitochondrial Disulfide Relay System : Roles in Oxidative Protein Folding and Beyond. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-495188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495188