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Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles
Joint Authors
Nohara, Satoshi
Jimbow, Kowichi
Yamamoto, Itsuo
Tamura, Yasuaki
Kamiya, Takafumi
Ito, Akira
Murase, Katsutoshi
Yoneta, Akihiro
Ito, Shosuke
Hasegawa, Takeo
Kobayashi, Takeshi
Honda, Hiroyuki
Yamashita, Toshiharu
Nakayama, Eiichi
Wakamatsu, Kazumasa
Ishii-Osai, Yasue
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Exploitation of biological properties unique to cancer cells may provide a novel approach to overcome difficult challenges to the treatment of advanced melanoma.
In order to develop melanoma-targeted chemothermoimmunotherapy, a melanogenesis substrate, N-propionyl-4-S-cysteaminylphenol (NPrCAP), sulfur-amine analogue of tyrosine, was conjugated with magnetite nanoparticles.
NPrCAP was exploited from melanogenesis substrates, which are expected to be selectively incorporated into melanoma cells and produce highly reactive free radicals through reacting with tyrosinase, resulting in chemotherapeutic and immunotherapeutic effects by oxidative stress and apoptotic cell death.
Magnetite nanoparticles were conjugated with NPrCAP to introduce thermotherapeutic and immunotherapeutic effects through nonapoptotic cell death and generation of heat shock protein (HSP) upon exposure to alternating magnetic field (AMF).
During these therapeutic processes, NPrCAP was also expected to provide melanoma-targeted drug delivery system.
American Psychological Association (APA)
Jimbow, Kowichi& Ishii-Osai, Yasue& Ito, Shosuke& Tamura, Yasuaki& Ito, Akira& Yoneta, Akihiro…[et al.]. 2013. Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles. Journal of Skin Cancer،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-495189
Modern Language Association (MLA)
Jimbow, Kowichi…[et al.]. Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles. Journal of Skin Cancer No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-495189
American Medical Association (AMA)
Jimbow, Kowichi& Ishii-Osai, Yasue& Ito, Shosuke& Tamura, Yasuaki& Ito, Akira& Yoneta, Akihiro…[et al.]. Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles. Journal of Skin Cancer. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-495189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495189