Immunohistochemical Analysis of the Activation Status of the AktmTORpS6 Signaling Pathway in Oral Lichen Planus
Joint Authors
Sklavounou, Alexandra
Nikitakis, Nikolaos G.
Prodromidis, Georgios
Source
International Journal of Dentistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Introduction.
Aberrations of the Akt/mTOR/pS6 pathway have been linked to various types of human cancer, including oral squamous cell carcinoma (OSCC).
The purpose of this study was to evaluate the activation status of Akt, mTOR, and pS6 in oral lichen planus (OLP) in comparison with oral premalignant and malignant lesions and normal oral mucosa (NM).
Materials and Methods.
Immunohistochemistry for p-Akt, p-mTOR, and phospho-pS6 was performed in 40 OLP, 20 oral leukoplakias (OL), 10 OSCC, and 10 control samples of NM.
Results.
Nuclear p-Akt expression was detected in the vast majority of cases in all categories, being significantly higher in OL.
Cytoplasmic p-Akt and p-mTOR staining was present only in a minority of OLP cases, being significantly lower compared to OL and OSCC.
Phospho-pS6 showed cytoplasmic positivity in most OLP cases, which however was significantly lower compared to OL and OSCC.
Conclusions.
Overall, cytoplasmic p-Akt, p-mTOR, and phospho-pS6 levels appear to be significantly lower in OLP compared to OL and OSCC.
However, the expression of these molecules in a subset of OLP cases suggests that activation of Akt/mTOR/pS6 may occur in the context of OLP, possibly contributing to the premalignant potential of individual cases.
American Psychological Association (APA)
Prodromidis, Georgios& Nikitakis, Nikolaos G.& Sklavounou, Alexandra. 2013. Immunohistochemical Analysis of the Activation Status of the AktmTORpS6 Signaling Pathway in Oral Lichen Planus. International Journal of Dentistry،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-495219
Modern Language Association (MLA)
Prodromidis, Georgios…[et al.]. Immunohistochemical Analysis of the Activation Status of the AktmTORpS6 Signaling Pathway in Oral Lichen Planus. International Journal of Dentistry No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-495219
American Medical Association (AMA)
Prodromidis, Georgios& Nikitakis, Nikolaos G.& Sklavounou, Alexandra. Immunohistochemical Analysis of the Activation Status of the AktmTORpS6 Signaling Pathway in Oral Lichen Planus. International Journal of Dentistry. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-495219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495219