The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Bisphenol A (BPA) is a monomer found in commonly used consumer plastic goods.
Although much attention in recent years has been placed on BPA’s impact as an endocrine disruptor, it also appears to activate many immune pathways involved in both autoimmune disease development and autoimmune reactivity provocation.
The current scientific literature is void of research papers linking BPA directly to human or animal onset of autoimmunity.
This paper explores the impact of BPA on immune reactivity and the potential roles these mechanisms may have on the development or provocation of autoimmune diseases.
Potential mechanisms by which BPA may be a contributing risk factor to autoimmune disease development and progression include its impact on hyperprolactinemia, estrogenic immune signaling, cytochrome P450 enzyme disruption, immune signal transduction pathway alteration, cytokine polarization, aryl hydrocarbon activation of Th-17 receptors, molecular mimicry, macrophage activation, lipopolysaccharide activation, and immunoglobulin pathophysiology.
In this paper a review of these known autoimmune triggering mechanisms will be correlated with BPA exposure, thereby suggesting that BPA has a role in the pathogenesis of autoimmunity.
American Psychological Association (APA)
Kharrazian, Datis. 2014. The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-495235
Modern Language Association (MLA)
Kharrazian, Datis. The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity. Autoimmune Diseases No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-495235
American Medical Association (AMA)
Kharrazian, Datis. The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-495235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495235