Mathematical Modeling of Cytotoxic Lymphocyte-Mediated Immune Response to Hepatitis B Virus Infection
Joint Authors
Huang, Sheng-He
Qi, Huan
Long, Changjiang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nowak's model of the human immunodeficiency virus (HIV) infection has been extensively and successfully used to simulate the interaction between HIV and cytotoxic lymphocyte- (CTL-) mediated immune response.
However, this model is not available for hepatitis B virus (HBV) infection.
As the enhanced recruitment of virus-specific CTLs into the liver has been an important novel concept in the pathogenesis of hepatitis B, we develop a specific mathematical model analyzing the relationship between HBV and the CTL-mediated immune response, and the indicator of the liver cell damage, alanine aminotransferase (ALT).
The stability condition of the complete recovery equilibrium point at which HBV will be eliminated entirely from the body is discussed.
A different set of parameters is used in the simulation, and the results show that the model can interpret the wide variety of clinical manifestations of HBV infection.
The model suggests that a rapid and vigorous CTL response is required for resolution of HBV infection.
American Psychological Association (APA)
Long, Changjiang& Qi, Huan& Huang, Sheng-He. 2008. Mathematical Modeling of Cytotoxic Lymphocyte-Mediated Immune Response to Hepatitis B Virus Infection. Journal of Biomedicine and Biotechnology،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-495244
Modern Language Association (MLA)
Long, Changjiang…[et al.]. Mathematical Modeling of Cytotoxic Lymphocyte-Mediated Immune Response to Hepatitis B Virus Infection. Journal of Biomedicine and Biotechnology No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-495244
American Medical Association (AMA)
Long, Changjiang& Qi, Huan& Huang, Sheng-He. Mathematical Modeling of Cytotoxic Lymphocyte-Mediated Immune Response to Hepatitis B Virus Infection. Journal of Biomedicine and Biotechnology. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-495244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495244