Exopolysaccharide from Ganoderma applanatum as a Promising Bioactive Compound with Cytostatic and Antibacterial Properties
Joint Authors
Janusz, Grzegorz
Osińska-Jaroszuk, Monika
Mizerska-Dudka, Magdalena
Jarosz-Wilkołazka, Anna
Błachowicz, Adriana
Polak, Jolanta
Kandefer-Szerszeń, Martyna
Jaszek, Magdalena
Wydrych, Jerzy
Rejczak, Tomasz Piotr
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect.
The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/mL) may exhibit selective activity against tumor cells (cell lines SiHa) and stimulate production of TNF-α THP-1-derived macrophages at the level of 752.17 pg/mL.
The GpEPS showed antibacterial properties against Staphyloccoccus aureus and a toxic effect against Vibrio fischeri cells (82.8% cell damage).
High cholesterol-binding capacity and triglycerides-binding capacity (57.9% and 41.6% after 24 h of incubation with the tested substances, resp.) were also detected for the investigated samples of GpEPS.
American Psychological Association (APA)
Osińska-Jaroszuk, Monika& Jaszek, Magdalena& Mizerska-Dudka, Magdalena& Błachowicz, Adriana& Rejczak, Tomasz Piotr& Janusz, Grzegorz…[et al.]. 2014. Exopolysaccharide from Ganoderma applanatum as a Promising Bioactive Compound with Cytostatic and Antibacterial Properties. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-495258
Modern Language Association (MLA)
Osińska-Jaroszuk, Monika…[et al.]. Exopolysaccharide from Ganoderma applanatum as a Promising Bioactive Compound with Cytostatic and Antibacterial Properties. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-495258
American Medical Association (AMA)
Osińska-Jaroszuk, Monika& Jaszek, Magdalena& Mizerska-Dudka, Magdalena& Błachowicz, Adriana& Rejczak, Tomasz Piotr& Janusz, Grzegorz…[et al.]. Exopolysaccharide from Ganoderma applanatum as a Promising Bioactive Compound with Cytostatic and Antibacterial Properties. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-495258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495258