Flow Cytometry as a Diagnostic Tool in the Early Diagnosis of Aggressive Lymphomas Mimicking Life-Threatening Infection
Joint Authors
Androutsos, Georgios
Tolis, Apostolos
Galanopoulos, Athanasios
Gortzolidis, Georgios
Tsagarakis, Nikolaos J.
Skoumi, Dimitra
Michaelidis, Christos
Rontogianni, Dimitra
Kakiopoulos, Georgios
Paterakis, Georgios
Tzanetou, Konstantina
Papadimitriou, Konstantinos A.
Kentrou, Nektaria A.
Chini, Stavroula
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aggressive lymphomas can present with symptoms mimicking life-threatening infection.
Flow cytometry (FC) is usually recommended for the classification and staging of lymphomas in patients with organomegaly and atypical cells in effusions and blood, after the exclusion of other possible diagnoses.
FC may also have a place in the initial diagnostic investigation of aggressive lymphoma.
Three cases are presented here of highly aggressive lymphomas in young adults, which presented with the clinical picture of fever of unknown origin (FUO) in patients severely ill.
All followed a life-threatening clinical course, and two developed the hemophagocytic syndrome (HPS), but microbiological, immunological, and morphological evaluation and immunohistochemistry (IHC) failed to substantiate an early diagnosis.
FC was the technique that provided conclusive diagnostic evidence of lymphoma, subsequently verified by IHC.
Our experience with these three cases highlights the potential role of FC as an adjunct methodology in the initial assessment of possible highly aggressive lymphoma presenting with the signs and symptoms of life-threatening infection, although the definitive diagnosis should be established by biopsy.
In such cases, FC can contribute to the diagnosis of lymphoma, independently of the presence of HPS.
American Psychological Association (APA)
Tsagarakis, Nikolaos J.& Kentrou, Nektaria A.& Kakiopoulos, Georgios& Androutsos, Georgios& Galanopoulos, Athanasios& Michaelidis, Christos…[et al.]. 2011. Flow Cytometry as a Diagnostic Tool in the Early Diagnosis of Aggressive Lymphomas Mimicking Life-Threatening Infection. Case Reports in Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-495261
Modern Language Association (MLA)
Tsagarakis, Nikolaos J.…[et al.]. Flow Cytometry as a Diagnostic Tool in the Early Diagnosis of Aggressive Lymphomas Mimicking Life-Threatening Infection. Case Reports in Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-495261
American Medical Association (AMA)
Tsagarakis, Nikolaos J.& Kentrou, Nektaria A.& Kakiopoulos, Georgios& Androutsos, Georgios& Galanopoulos, Athanasios& Michaelidis, Christos…[et al.]. Flow Cytometry as a Diagnostic Tool in the Early Diagnosis of Aggressive Lymphomas Mimicking Life-Threatening Infection. Case Reports in Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-495261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495261