Exogenous High-Mobility Group Box 1 Protein Injection Improves Cardiac Function after Myocardial Infarction : Involvement of Wnt Signaling Activation
Joint Authors
Zhou, Xiaoya
Xu, Changwu
Jiang, Hong
Hu, Xiaorong
Xu, Weipan
Xie, Jing
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Exogenous high-mobility group box 1 protein (HMGB1) injection could prevent left ventricular remodeling and enhance left ventricular function during myocardial infarction (MI).
However, the mechanism remains unclear.
This paper was to investigate in the mechanism of cardioprotection of HMGB1 during MI in rats.
Anesthetized male rats were treated once with HMGB1 (200 ng) 4 h after MI and then executed after 7 and 28 days, respectively.
Cardiac function, collagen deposition, and dishevelled-1 and β-catenin protein expression were measured.
After MI 7 days or 28 days, the left ventricular ejection fraction (LVEF) was significantly decreased compared to that of sham-operated control group (P<0.05).
However, the LVEF HMGB1-treated groups were significantly higher compared to those of the MI group in both 7 days and 28 days (P<0.05).
The collagen volume fraction was significantly reduced in the HMGB1-treated group in infarcted border zone.
HMGB1 could activate the expression of dishevelled-1 and β-catenin proteins (P<0.05).
Our study suggested that exogenous high-mobility group box 1 protein injection improves cardiac function after MI, which may be involved in Wnt/β-catenin signaling activation.
American Psychological Association (APA)
Zhou, Xiaoya& Hu, Xiaorong& Xie, Jing& Xu, Changwu& Xu, Weipan& Jiang, Hong. 2012. Exogenous High-Mobility Group Box 1 Protein Injection Improves Cardiac Function after Myocardial Infarction : Involvement of Wnt Signaling Activation. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-495273
Modern Language Association (MLA)
Zhou, Xiaoya…[et al.]. Exogenous High-Mobility Group Box 1 Protein Injection Improves Cardiac Function after Myocardial Infarction : Involvement of Wnt Signaling Activation. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-495273
American Medical Association (AMA)
Zhou, Xiaoya& Hu, Xiaorong& Xie, Jing& Xu, Changwu& Xu, Weipan& Jiang, Hong. Exogenous High-Mobility Group Box 1 Protein Injection Improves Cardiac Function after Myocardial Infarction : Involvement of Wnt Signaling Activation. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-495273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495273