Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients

Abstract EN

CA19-9 is a tumor-associated antigen.

It is also a marker of pancreatic tissue damage that might be caused by diabetes.

Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level.

Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model.

This study firstly found total cholesterol was one of the independent contributors to CA19-9.

Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level.