Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γIL-4 Ratio In Utero in Pregnant Mice
Joint Authors
Zhao, Yantao
Shi, Wanyu
Ma, Aituan
Geng, Meiying
Zhong, Xiuhui
Wang, Xiaodan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The objective of this study is to investigate the antiabortive effects of Quercetin and Bornvl Acetate and their immunological modulation at maternal-fetal interface.
Lipopolysaccharide (LPS) was injected via tail vein to induce abortion in mice which received Quercetin and Bornvl Acetate at days 4–7 of gestation.
Uterine CD4+/CD8+ T lymphocytes and IFN-γ/IL-4 of each group (n=10) were detected by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.
The ratio of CD4+/CD8+ increased significantly (P<.01) in the uterus of LPS-induced abortion mice.
In the Quercetin and Bornvl Acetate pretreated mice followed by LPS administration, the ratio of CD4+/CD8+ dropped to 0.562±0.021, lower than that of LPS-abortion group (P<.01).
The mean value of IFN-γ/IL-4 in LPS-treated mice was 0.310±0.066, higher than that of Quercetin and Bornyl Acetate group.
The results indicate that Quercetin and Bornyl Acetate have an antiabortive effect through modulation of immunological balance at maternal-fetal interface.
American Psychological Association (APA)
Wang, Xiaodan& Ma, Aituan& Shi, Wanyu& Geng, Meiying& Zhong, Xiuhui& Zhao, Yantao. 2010. Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γIL-4 Ratio In Utero in Pregnant Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-495313
Modern Language Association (MLA)
Wang, Xiaodan…[et al.]. Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γIL-4 Ratio In Utero in Pregnant Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-495313
American Medical Association (AMA)
Wang, Xiaodan& Ma, Aituan& Shi, Wanyu& Geng, Meiying& Zhong, Xiuhui& Zhao, Yantao. Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γIL-4 Ratio In Utero in Pregnant Mice. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-495313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495313
