Novel Biphasic Role of LipoxinA4 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts

Joint Authors

Zheng, Shengxing
Lian, Qing-Quan
Ye, Duyun
Jin, Sheng-Wei
Song, Xiaorong
Smith, Fang Gao
He, Qian
Wang, Qian

Source

Mediators of Inflammation

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-07-02

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases

Abstract EN

Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well.

As the endogenous “braking signal”, Lipoxins can regulate anti-inflammation and the resolution of inflammation.

We investigated the effect of lipoxinA4 on the expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts.

We demonstrated that the expression of cyclooxygenase-2 protein was significantly increased and peaked initially at 6 hours, with a second increase, with maximal levels occurring 24 hours after lipopolysaccharide challenge.

ProstaglandinE2 levels also peaked at 6 hours, and prostaglandinD2 levels were increased at both 6 and 24 hours.

Exogenous lipoxinA4 inhibited the first peak of cyclooxygenase-2 expression as well as the production of prostaglandinE2 induced by lipopolysaccharide in a dose-dependent manner.

In contrast, exogenous lipoxinA4 increased the second peak of cyclooxygenase-2 expression as well as the production of prostaglandinD2 induced by lipopolysaccharide in a dose-dependent manner.

LipoxinA4 receptor mRNA expression was markedly stimulated by lipopolysaccharide but inhibited by lipoxinA4.

We present evidence for a novel biphasic role of lipoxinA4 on the expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts, whereby LXA4 has an anti-inflammatory and proresolving activity in lung fibroblasts following LPS stimulation.

American Psychological Association (APA)

Zheng, Shengxing& Wang, Qian& He, Qian& Song, Xiaorong& Ye, Duyun& Smith, Fang Gao…[et al.]. 2011. Novel Biphasic Role of LipoxinA4 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-495320

Modern Language Association (MLA)

Zheng, Shengxing…[et al.]. Novel Biphasic Role of LipoxinA4 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts. Mediators of Inflammation No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-495320

American Medical Association (AMA)

Zheng, Shengxing& Wang, Qian& He, Qian& Song, Xiaorong& Ye, Duyun& Smith, Fang Gao…[et al.]. Novel Biphasic Role of LipoxinA4 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-495320

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-495320