Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis
Joint Authors
Oliaee, Davood
Ghorbani, Ahmad
Boroushaki, Mohammad Taher
Oliaee, Naiime
Source
Advances in Pharmacological Sciences
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
To date, there is no report on safety of Artemisia Kopetdaghensis.
This study aimed to determine the possible undesirable effects of A.
Kopetdaghensis on reproduction of female rats.
The pregnant rats were treated (i.p.) with vehicle or 200 and 400 mg/kg of A.
Kopetdaghensis hydroalcoholic extract from the 2nd to 8th day of pregnancy.
Then, number and weight of neonates, duration of pregnancy, and percent of dead fetuses were determined.
Also, cytotoxicity of this plant was tested using fibroblast (L929) and ovary (Cho) cell lines.
The A.
Kopetdaghensis had no significant effect on duration of pregnancy, average number of neonates, and weight of neonates.
However, administration of 200 and 400 mg/kg of the extract led to 30 and 44% abortion in animals, respectively.
The extract at concentrations ≥200 μg/mL significantly (P<0.001) inhibited the proliferation of L929 fibroblast cells.
Regarding the Cho cells, the extract induced toxicity only at concentration of 800 μg/mL (P<0.01).
Our results showed that continuous consumption of A.
Kopetdaghensis in pregnancy may increase the risk of abortion and also may have toxic effect on some cells.
American Psychological Association (APA)
Oliaee, Davood& Boroushaki, Mohammad Taher& Oliaee, Naiime& Ghorbani, Ahmad. 2014. Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis. Advances in Pharmacological Sciences،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-495347
Modern Language Association (MLA)
Oliaee, Davood…[et al.]. Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis. Advances in Pharmacological Sciences No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-495347
American Medical Association (AMA)
Oliaee, Davood& Boroushaki, Mohammad Taher& Oliaee, Naiime& Ghorbani, Ahmad. Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis. Advances in Pharmacological Sciences. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-495347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495347