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Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis
Joint Authors
Chaparro, Cecilia
Tullis, D. Elizabeth
Zhang, Yu
Hwang, David M.
Cypel, Marcelo
Maughan, Heather
Guttman, David S.
Waddell, Thomas K.
Keshavjee, Shaf
Cunningham, Kristopher S.
Wang, Pauline W.
Liu, Mingyao
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Recurrent bacterial infections play a key role in the pathogenesis of bronchiectasis, but conventional microbiologic methods may fail to identify pathogens in many cases.
We characterized and compared the pulmonary bacterial communities of cystic fibrosis (CF) and non-CF bronchiectasis patients using a culture-independent molecular approach.
Methods.
Bacterial 16S rRNA gene libraries were constructed from lung tissue of 10 non-CF bronchiectasis and 21 CF patients, followed by DNA sequencing of isolates from each library.
Community characteristics were analyzed and compared between the two groups.
Results.
A wide range of bacterial diversity was detected in both groups, with between 1 and 21 bacterial taxa found in each patient.
Pseudomonas was the most common genus in both groups, comprising 49% of sequences detected and dominating numerically in 13 patients.
Although Pseudomonas appeared to be dominant more often in CF patients than in non-CF patients, analysis of entire bacterial communities did not identify significant differences between these two groups.
Conclusions.
Our data indicate significant diversity in the pulmonary bacterial community of both CF and non-CF bronchiectasis patients and suggest that this community is similar in surgically resected lungs of CF and non-CF bronchiectasis patients.
American Psychological Association (APA)
Maughan, Heather& Cunningham, Kristopher S.& Wang, Pauline W.& Zhang, Yu& Cypel, Marcelo& Chaparro, Cecilia…[et al.]. 2012. Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-495402
Modern Language Association (MLA)
Maughan, Heather…[et al.]. Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis. Pulmonary Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-495402
American Medical Association (AMA)
Maughan, Heather& Cunningham, Kristopher S.& Wang, Pauline W.& Zhang, Yu& Cypel, Marcelo& Chaparro, Cecilia…[et al.]. Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-495402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495402