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The Involvement of NRF2 in Lung Cancer
Joint Authors
Bauer, Alison K.
Alexander, Carla-Maria
Hill, Thomas
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Nuclear factor, erythroid-derived 2, like 2 (NRF2) is a key regulator of antioxidants and cellular stress responses.
The role of NRF2 in pulmonary neoplasia, a diverse disease for which few biomarkers exist, is complicated and appears to depend on several main factors including the existence of activating mutations in NRF2 and/or loss of function mutations in KEAP1 and the stage of carcinogenesis studied, particularly in the mouse models tested.
Therapeutic strategies for lung cancer targeting NRF2 have observed mixed results, both anti- and protumorigenic effects; however, these differences seem to reflect the mutation status of NRF2 or KEAP1.
In this paper, we will discuss the studies on human NRF2 and the mechanisms proposed, several mouse models using various mice deficient in NRF2, as well as xenograft models, and the chemotherapeutic strategies using the NRF2 pathway.
American Psychological Association (APA)
Bauer, Alison K.& Hill, Thomas& Alexander, Carla-Maria. 2013. The Involvement of NRF2 in Lung Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495416
Modern Language Association (MLA)
Bauer, Alison K.…[et al.]. The Involvement of NRF2 in Lung Cancer. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-495416
American Medical Association (AMA)
Bauer, Alison K.& Hill, Thomas& Alexander, Carla-Maria. The Involvement of NRF2 in Lung Cancer. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495416