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Death Receptors in the Selective Degeneration of Motoneurons in Amyotrophic Lateral Sclerosis
Joint Authors
Bernard-Marissal, Nathalie
Pettmann, Brigitte
Aebischer, Julianne
Raoul, Cédric
Source
Journal of Neurodegenerative Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
While studies on death receptors have long been restricted to immune cells, the last decade has provided a strong body of evidence for their implication in neuronal death and hence neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS).
ALS is a fatal paralytic disorder that primarily affects motoneurons in the brain and spinal cord.
A neuroinflammatory process, associated with astrocyte and microglial activation as well as infiltration of immune cells, accompanies motoneuron degeneration and supports the contribution of non-cell-autonomous mechanisms in the disease.
Hallmarks of Fas, TNFR, LT-βR, and p75NTR signaling have been observed in both animal models and ALS patients.
This review summarizes to date knowledge of the role of death receptors in ALS and the link existing between the selective loss of motoneurons and neuroinflammation.
It further suggests how this recent evidence could be included in an ultimate multiapproach to treat patients.
American Psychological Association (APA)
Aebischer, Julianne& Bernard-Marissal, Nathalie& Pettmann, Brigitte& Raoul, Cédric. 2013. Death Receptors in the Selective Degeneration of Motoneurons in Amyotrophic Lateral Sclerosis. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-495450
Modern Language Association (MLA)
Aebischer, Julianne…[et al.]. Death Receptors in the Selective Degeneration of Motoneurons in Amyotrophic Lateral Sclerosis. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-495450
American Medical Association (AMA)
Aebischer, Julianne& Bernard-Marissal, Nathalie& Pettmann, Brigitte& Raoul, Cédric. Death Receptors in the Selective Degeneration of Motoneurons in Amyotrophic Lateral Sclerosis. Journal of Neurodegenerative Diseases. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-495450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495450