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Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii : An In Vivo Study on Natural Aging Rat Model
Joint Authors
Xie, Qing-Feng
Li, Kun-Yin
Dong, Tina Ting-Xia
Tsim, Karl Wah-Keung
Tang, Li-Hai
Lai, Xiao-Ping
Su, Ji-Yan
Liu, Dan-Dan
Liu, Wei-Jin
Lai, Ping
Su, Zi-Ren
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) has been extensively applied as preferable herbal remedy for menopausal symptoms.
In the present work, the potential of a TCM recipe named RRF, composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii, was investigated on a natural aging rat model.
After administration of RRF (141, 282, and 564 mg/kg/d), the circulated estradiol (E2) level increased accompanied by a reduction of serum follicle stimulating hormone (FSH).
But no significant impact on serum lutenizing hormone (LH) level was observed.
As a result of the E2-FSH-LH adjustment, the histomorphology degenerations of ovary, uterus, and vagina of the 11.5-month female rats were alleviated.
And lumbar vertebrae trabecular microstructure was also restored under RRF exposure by means of increasing the trabecular area and area rate.
Moreover, levels of hypothalamic dopamine (DA) and norepinephrine (NE) rallied significantly after RRF treatment.
Results from our studies suggest that RRF possesses a positive regulation on the estrogen imbalance and neurotransmitter disorder, thereby restoring reproductive organ degeneration and skeleton deterioration.
The above-mentioned benefits of RRF on the menopause syndromes recommend RRF as a potential candidate for the treatment of perimenopausal syndrome.
American Psychological Association (APA)
Su, Ji-Yan& Xie, Qing-Feng& Liu, Wei-Jin& Lai, Ping& Liu, Dan-Dan& Tang, Li-Hai…[et al.]. 2013. Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii : An In Vivo Study on Natural Aging Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-495483
Modern Language Association (MLA)
Su, Ji-Yan…[et al.]. Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii : An In Vivo Study on Natural Aging Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-495483
American Medical Association (AMA)
Su, Ji-Yan& Xie, Qing-Feng& Liu, Wei-Jin& Lai, Ping& Liu, Dan-Dan& Tang, Li-Hai…[et al.]. Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii : An In Vivo Study on Natural Aging Rat Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-495483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495483