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Sargassum fulvellum Protects HaCaT Cells and BALBc Mice from UVB-Induced Proinflammatory Responses
Joint Authors
Ahn, Eun Mi
Park, Chan-Ik
Lee, Chan
Jang, Jung-Hee
Park, Gyu Hwan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ultraviolet (UV) radiation has been reported to induce cutaneous inflammation such as erythema and edema via induction of proinflammatory enzymes and mediators.
Sargassum fulvellum is a brown alga of Sargassaceae family which has been demonstrated to exhibit antipyretic, analgesic, antiedema, antioxidant, antitumor, fibrinolytic, and hepatoprotective activities.
The purpose of this study is to investigate anti-inflammatory effects of ethylacetate fraction of ethanol extract of Sargassum fulvellum (SFE-EtOAc) in HaCaT keratinocytes and BALB/c mice.
In HaCaT cells, SFE-EtOAc effectively inhibited UVB-induced cytotoxicity (60 mJ/cm2) and the expression of proinflammatory proteins such as cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and inducible nitric oxide synthase (iNOS).
Furthermore, SFE-EtOAc significantly reduced UVB-induced production of proinflammatory mediators including prostaglandin E2 (PGE2) and nitric oxide (NO).
In BALB/c mice, topical application of SFE-EtOAc prior to UVB irradiation (200 mJ/cm2) effectively suppressed the UVB-induced protein expression of COX-2, iNOS, and TNF-α and subsequently attenuated generation of PGE2 and NO as well.
In another experiment, SFE-EtOAc pretreatment suppressed UVB-induced reactive oxygen species production and exhibited an antioxidant potential by upregulation of antioxidant enzymes such as catalase and Cu/Zn-superoxide dismutase in HaCaT cells.
These results suggest that SFE-EtOAc could be an effective anti-inflammatory agent protecting against UVB irradiation-induced skin damages.
American Psychological Association (APA)
Lee, Chan& Park, Gyu Hwan& Ahn, Eun Mi& Park, Chan-Ik& Jang, Jung-Hee. 2013. Sargassum fulvellum Protects HaCaT Cells and BALBc Mice from UVB-Induced Proinflammatory Responses. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495519
Modern Language Association (MLA)
Lee, Chan…[et al.]. Sargassum fulvellum Protects HaCaT Cells and BALBc Mice from UVB-Induced Proinflammatory Responses. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-495519
American Medical Association (AMA)
Lee, Chan& Park, Gyu Hwan& Ahn, Eun Mi& Park, Chan-Ik& Jang, Jung-Hee. Sargassum fulvellum Protects HaCaT Cells and BALBc Mice from UVB-Induced Proinflammatory Responses. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495519