Superparamagnetic Bifunctional Bisphosphonates Nanoparticles : A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic
Joint Authors
Monteil, M.
Serfaty, J. M.
Weinmann, P.
Motte, L.
Jouni, H.
Lalatonne, Y.
Sainte-Catherine, O.
Kusmia, S.
Lièvre, N.
Lecouvey, M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system.
This new targeting nanoplatform consists of superparamagnetic γFe2O3 nanoparticles conjugated to 1,5-dihydroxy-1,5,5-tris-phosphono-pentyl-phosphonic acid (di-HMBPs) molecules with a bisphosphonate function at the outer of the nanoparticle surface for bone targeting.
The as-synthesized nanoparticles were evaluated as a specific MRI contrast agent by adsorption study onto hydroxyapatite and MRI measurment.
The strong adsorption of the bisphosphonates nanoparticles to hydroxyapatite and their use as MRI T2∗ contrast agent were demonstrated.
Cellular tests performed on human osteosarcoma cells (MG63) show that γFe2O3@di-HMBP hybrid nanomaterial has no citoxity effect in cell viability and may act as a diagnostic and therapeutic system.
American Psychological Association (APA)
Lalatonne, Y.& Monteil, M.& Jouni, H.& Serfaty, J. M.& Sainte-Catherine, O.& Lièvre, N.…[et al.]. 2010. Superparamagnetic Bifunctional Bisphosphonates Nanoparticles : A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic. Journal of Osteoporosis،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-495520
Modern Language Association (MLA)
Lalatonne, Y.…[et al.]. Superparamagnetic Bifunctional Bisphosphonates Nanoparticles : A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic. Journal of Osteoporosis No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-495520
American Medical Association (AMA)
Lalatonne, Y.& Monteil, M.& Jouni, H.& Serfaty, J. M.& Sainte-Catherine, O.& Lièvre, N.…[et al.]. Superparamagnetic Bifunctional Bisphosphonates Nanoparticles : A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic. Journal of Osteoporosis. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-495520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495520