Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease
Joint Authors
Polvani, Simone
Mello, Tommaso
Galli, Andrea
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
A growing number of new studies demonstrate that nuclear receptors are involved in the development of alcoholic liver disease (ALD).
Ethanol metabolism and RXR/PPAR functions are tightly interconnected in the liver.
Several ethanol metabolizing enzymes are potently regulated by RXR and PPARα after alcohol consumption.
The increased ethanol metabolism, in turn, leads to alteration of the redox balance of the cells and impairment of RXR/PPAR functions by direct and indirect effects of acetaldehyde, resulting in deranged lipid metabolism, oxidative stress, and release of proinflammatory cytokines.
The use of animal models played a crucial role in understanding the molecular mechanisms of ALD.
In this paper we summarize the reciprocal interactions between ethanol metabolism and RXR/PPAR functions.
In conclusion, RXR and PPAR play a central role in the onset and perpetuation of the mechanisms underling all steps of the clinical progression in ALD.
American Psychological Association (APA)
Mello, Tommaso& Polvani, Simone& Galli, Andrea. 2009. Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease. PPAR Research،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-495550
Modern Language Association (MLA)
Mello, Tommaso…[et al.]. Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease. PPAR Research No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-495550
American Medical Association (AMA)
Mello, Tommaso& Polvani, Simone& Galli, Andrea. Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-495550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495550