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Host-Parasite Interaction : Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix
Joint Authors
de la Garza, Mireya
Piña-Vázquez, Carolina
Serrano-Luna, Jesús
Reyes-López, Magda
Ortíz-Estrada, Guillermo
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Parasitic protozoa are among the most important pathogens worldwide.
Diseases such as malaria, leishmaniasis, amoebiasis, giardiasis, trichomoniasis, and trypanosomiasis affect millions of people.
Humans are constantly threatened by infections caused by these pathogens.
Parasites engage a plethora of surface and secreted molecules to attach to and enter mammalian cells.
The secretion of lytic enzymes by parasites into host organs mediates critical interactions because of the invasion and destruction of interstitial tissues, enabling parasite migration to other sites within the hosts.
Extracellular matrix is a complex, cross-linked structure that holds cells together in an organized assembly and that forms the basement membrane lining (basal lamina).
The extracellular matrix represents a major barrier to parasites.
Therefore, the evolution of mechanisms for connective-tissue degradation may be of great importance for parasite survival.
Recent advances have been achieved in our understanding of the biochemistry and molecular biology of proteases from parasitic protozoa.
The focus of this paper is to discuss the role of protozoan parasitic proteases in the degradation of host ECM proteins and the participation of these molecules as virulence factors.
We divide the paper into two sections, extracellular and intracellular protozoa.
American Psychological Association (APA)
Piña-Vázquez, Carolina& Reyes-López, Magda& Ortíz-Estrada, Guillermo& de la Garza, Mireya& Serrano-Luna, Jesús. 2012. Host-Parasite Interaction : Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-495555
Modern Language Association (MLA)
Piña-Vázquez, Carolina…[et al.]. Host-Parasite Interaction : Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix. Journal of Parasitology Research No. 2012 (2012), pp.1-24.
https://search.emarefa.net/detail/BIM-495555
American Medical Association (AMA)
Piña-Vázquez, Carolina& Reyes-López, Magda& Ortíz-Estrada, Guillermo& de la Garza, Mireya& Serrano-Luna, Jesús. Host-Parasite Interaction : Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-495555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495555