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Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State
Joint Authors
Luis, Santiago V.
Burguete, M. Isabel
Martí-Centelles, Vicente
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Several kinetic models for the macrocyclization of a C2 pseudopeptide with a dihalide through a SN2 reaction have been developed.
These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the competitive oligomerization/polymerization processes yielding undesired oligomeric/polymeric byproducts.
The effect of anions has also been included in the kinetic models, as they can act as catalytic templates in the transition state reducing and stabilizing the transition state.
The corresponding differential equation systems for each kinetic model can be solved numerically.
Through a comprehensive analysis of these results, it is possible to obtain a better understanding of the different parameters that are involved in the macrocyclization reaction mechanism and to develop strategies for the optimization of the desired processes.
American Psychological Association (APA)
Martí-Centelles, Vicente& Burguete, M. Isabel& Luis, Santiago V.. 2012. Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-495561
Modern Language Association (MLA)
Martí-Centelles, Vicente…[et al.]. Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State. The Scientific World Journal No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-495561
American Medical Association (AMA)
Martí-Centelles, Vicente& Burguete, M. Isabel& Luis, Santiago V.. Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-495561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495561