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Looking beyond Androgen Receptor Signaling in the Treatment of Advanced Prostate Cancer
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This review will provide a description of recent efforts in our laboratory contributing to a general goal of identifying critical determinants of prostate cancer growth in both androgen-dependent and -independent contexts.
Important outcomes to date have indicated that the sustained activation of AR transcriptional activity in castration-resistant prostate cancer (CRPC) cells results in a gene expression profile separate from the androgen-responsive profile of androgen-dependent prostate cancer (ADPC) cells.
Contributing to this reprogramming is enhanced FoxA1 recruitment of AR to G2/M phase target gene loci and the enhanced chromatin looping of CRPC-specific gene regulatory elements facilitated by PI3K/Akt-phosphorylated MED1.
We have also observed a role for FoxA1 beyond AR signaling in driving G1/S phase cell cycle progression that relies on interactions with novel collaborators MYBL2 and CREB1.
Finally, we describe an in-depth mechanism of GATA2-mediated androgen-responsive gene expression in both ADPC and CRPC cells.
Altogether these efforts provide evidence to support the development of novel prostate cancer therapeutics that address downstream targets of AR activity as well as AR-independent drivers of disease-relevant transcription programs.
American Psychological Association (APA)
Sunkel, Benjamin& Wang, Qianben. 2014. Looking beyond Androgen Receptor Signaling in the Treatment of Advanced Prostate Cancer. Advances in Andrology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-495571
Modern Language Association (MLA)
Sunkel, Benjamin& Wang, Qianben. Looking beyond Androgen Receptor Signaling in the Treatment of Advanced Prostate Cancer. Advances in Andrology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-495571
American Medical Association (AMA)
Sunkel, Benjamin& Wang, Qianben. Looking beyond Androgen Receptor Signaling in the Treatment of Advanced Prostate Cancer. Advances in Andrology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-495571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495571