Transmission of Onchocerciasis in Wadelai Focus of Northwestern Uganda Has Been Interrupted and the Disease Eliminated
Joint Authors
Habomugisha, Peace
Byamukama, Edson
Lakwo, Thomson L.
Tukesiga, Ephraim
Agunyo, Stella
Unnasch, Thomas R.
Ndyomugyenyi, Richard
Unoba, Dickson
Richards, Frank O.
Walsh, Frank
Katabarwa, Moses N.
Oguttu, David W.
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Wadelai, an isolated focus for onchocerciasis in northwest Uganda, was selected for piloting an onchocerciasis elimination strategy that was ultimately the precursor for countrywide onchocerciasis elimination policy.
The Wadelai focus strategy was to increase ivermectin treatments from annual to semiannual frequency and expand geographic area in order to include communities with nodule rate of less than 20%.
These communities had not been covered by the previous policy that sought to control onchocerciasis only as a public health problem.
From 2006 to 2010, Wadelai program successfully attained ultimate treatment goal (UTG), treatment coverage of ≥90%, despite expanding from 19 to 34 communities and from 5,600 annual treatments to over 29,000 semiannual treatments.
Evaluations in 2009 showed no microfilaria in skin snips of over 500 persons examined, and only 1 of 3011 children was IgG4 antibody positive to the OV16 recombinant antigen.
No Simulium vectors were found, and their disappearance could have sped up interruption of transmission.
Although twice-per-year treatment had an unclear role in interruption of transmission, the experience demonstrated that twice-per-year treatment is feasible in the Ugandan setting.
The monitoring data support the conclusion that onchocerciasis has been eliminated from the Wadelai focus of Uganda.
American Psychological Association (APA)
Katabarwa, Moses N.& Walsh, Frank& Habomugisha, Peace& Lakwo, Thomson L.& Agunyo, Stella& Oguttu, David W.…[et al.]. 2012. Transmission of Onchocerciasis in Wadelai Focus of Northwestern Uganda Has Been Interrupted and the Disease Eliminated. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-495586
Modern Language Association (MLA)
Katabarwa, Moses N.…[et al.]. Transmission of Onchocerciasis in Wadelai Focus of Northwestern Uganda Has Been Interrupted and the Disease Eliminated. Journal of Parasitology Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-495586
American Medical Association (AMA)
Katabarwa, Moses N.& Walsh, Frank& Habomugisha, Peace& Lakwo, Thomson L.& Agunyo, Stella& Oguttu, David W.…[et al.]. Transmission of Onchocerciasis in Wadelai Focus of Northwestern Uganda Has Been Interrupted and the Disease Eliminated. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-495586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495586