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Targeting Sonic Hedgehog Signaling by Compounds and Derivatives from Natural Products
Joint Authors
Liao, Hui-Fen
Chao, K. S. Clifford
Huang, Yu-Chuen
Chen, Yu-Jen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cancer stem cells (CSCs) are a major cause of cancer treatment failure, relapse, and drug resistance and are known to be responsible for cancer cell invasion and metastasis.
The Sonic hedgehog (Shh) signaling pathway is crucial to embryonic development.
Intriguingly, the aberrant activation of the Shh pathway plays critical roles in developing CSCs and leads to angiogenesis, migration, invasion, and metastasis.
Natural compounds and chemical structure modified derivatives from complementary and alternative medicine have received increasing attention as cancer chemopreventives, and their antitumor effects have been demonstrated both in vitro and in vivo.
However, reports for their bioactivity against CSCs and specifically targeting Shh signaling remain limited.
In this review, we summarize investigations of the compounds cyclopamine, curcumin, epigallocatechin-3-gallate, genistein, resveratrol, zerumbone, norcantharidin, and arsenic trioxide, with a focus on Shh signaling blockade.
Given that Shh signaling antagonism has been clinically proven as effective strategy against CSCs, this review may be exploitable for development of novel anticancer agents from complementary and alternative medicine.
American Psychological Association (APA)
Huang, Yu-Chuen& Chao, K. S. Clifford& Liao, Hui-Fen& Chen, Yu-Jen. 2013. Targeting Sonic Hedgehog Signaling by Compounds and Derivatives from Natural Products. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-495594
Modern Language Association (MLA)
Huang, Yu-Chuen…[et al.]. Targeting Sonic Hedgehog Signaling by Compounds and Derivatives from Natural Products. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-495594
American Medical Association (AMA)
Huang, Yu-Chuen& Chao, K. S. Clifford& Liao, Hui-Fen& Chen, Yu-Jen. Targeting Sonic Hedgehog Signaling by Compounds and Derivatives from Natural Products. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-495594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495594