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Antiresorptive Activity of Bacillus-Fermented Antler Extracts : Inhibition of Osteoclast Differentiation
Joint Authors
Kim, So I.
Kwon, Dae Young
Yang, Hye Jeong
Chae, Eun Jeong
Moon, Seong-Hee
Kim, Young Su
Kim, Seong Hwan
Choi, Sik-Won
Yu, Ri
Park, Sang-Joon
Son, Young-Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Antlers have been traditionally used for thousands of years as a natural product with medicinal and pharmaceutical properties.
In developing healthy foods, Bacillus-mediated fermentation is widely used to enhance the biological activity of nutrients in foods.
Recently, fermentation was shown to enhance the osteogenic activity of antlers.
This study aimed to elucidate the antiresorptive activity of Bacillus-fermented antler and its mode of action.
We found that Bacillus-fermented antler extract strongly inhibited osteoclast differentiation by downregulating the expression and activity of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1).
This extract also inhibited the activation of phospholipase Cγ2 (PLCγ2), a signaling molecule that could regulate NFATc1 transcriptional activity.
This suggested that Bacillus-fermented antler extract could inhibit PLCγ2-NFATc1 signaling required for bone resorption and cell fusion.
Consequently, Bacillus-fermented antler extract might benefit osteoclast-related disorders, including osteoporosis; furthermore, it may improve gastrointestinal activity.
American Psychological Association (APA)
Choi, Sik-Won& Moon, Seong-Hee& Yang, Hye Jeong& Kwon, Dae Young& Son, Young-Jin& Yu, Ri…[et al.]. 2013. Antiresorptive Activity of Bacillus-Fermented Antler Extracts : Inhibition of Osteoclast Differentiation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-495607
Modern Language Association (MLA)
Choi, Sik-Won…[et al.]. Antiresorptive Activity of Bacillus-Fermented Antler Extracts : Inhibition of Osteoclast Differentiation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-495607
American Medical Association (AMA)
Choi, Sik-Won& Moon, Seong-Hee& Yang, Hye Jeong& Kwon, Dae Young& Son, Young-Jin& Yu, Ri…[et al.]. Antiresorptive Activity of Bacillus-Fermented Antler Extracts : Inhibition of Osteoclast Differentiation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-495607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495607