Challenges and Opportunities for Small Molecule Aptamer Development
Joint Authors
McKeague, Maureen
DeRosa, Maria C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity.
Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics.
Despite this potential, relatively few aptamers exist that bind to small molecules.
Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses.
Novel, effective molecular recognition probes for these compounds are therefore of great interest.
This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology.
American Psychological Association (APA)
McKeague, Maureen& DeRosa, Maria C.. 2012. Challenges and Opportunities for Small Molecule Aptamer Development. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-495619
Modern Language Association (MLA)
McKeague, Maureen& DeRosa, Maria C.. Challenges and Opportunities for Small Molecule Aptamer Development. Journal of Nucleic Acids No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-495619
American Medical Association (AMA)
McKeague, Maureen& DeRosa, Maria C.. Challenges and Opportunities for Small Molecule Aptamer Development. Journal of Nucleic Acids. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-495619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495619