Hemoglobin Disorders in South India
Joint Authors
Soni, Mamta
Chandrashekar, Vani
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cation exchange-high performance liquid chromatography (CE-HPLC) is increasingly being used as a first line of investigation for hemoglobinopathies and thalassemias.
Together with a complete blood count, the CE-HPLC is effective in categorizing hemoglobinopathies as traits, homozygous disorders and compound heterozygous disorders.
We carried out a one year study in Apollo Hospitals, Chennai (Tamil Nadu, South India) during which 543 abnormal chromatogram patterns were seen.
The commonest disorder we encountered was β-thalassemia trait (37.9%), followed by HbE trait (23.2%), homozygous HbE disease (18.9%), HbS trait (5.3%), HbE β-thalassemia (4.6%), HbS β-thalassemia (2.5%), β-thalassemia major (2.3%), HbH (1.6%), homozygous HbS (1.4%), HbD trait (0.7%).
The average value of HbA2 in β-thalassemia minor was 5.4%.
β-thalassemia major had an average HbF of 88% and in HbH the mean A2 was 1.4%.
Among the HbE disorders the HbA2 + HbE was 30.1% in the heterozygous state, 90.8% in the homozygous state and 54.8% in HbE β-thalassemia.
In the sickle cell disorders, HbS varied from 30.9% in the trait to 79.9% in the homozygous state to 65.6% in HbS β-thalassemia.
American Psychological Association (APA)
Chandrashekar, Vani& Soni, Mamta. 2011. Hemoglobin Disorders in South India. ISRN Hematology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-495624
Modern Language Association (MLA)
Chandrashekar, Vani& Soni, Mamta. Hemoglobin Disorders in South India. ISRN Hematology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-495624
American Medical Association (AMA)
Chandrashekar, Vani& Soni, Mamta. Hemoglobin Disorders in South India. ISRN Hematology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-495624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495624