The Glomerular Filtration Barrier : Components and Crosstalk
Joint Authors
Chuang, Peter Y.
He, Cijiang John
Menon, Madhav C.
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules.
Its integrity is maintained by physicochemical and signalling interplay among its three core constituents—the glomerular endothelial cell, the basement membrane and visceral epithelial cell (podocyte).
Understanding the pathomechanisms of inherited and acquired human diseases as well as experimental injury models of this barrier have helped to unravel this interdependence.
Key among the consequences of interference with the integrity of the glomerular filtration barrier is the appearance of significant amounts of proteins in the urine.
Proteinuria correlates with kidney disease progression and cardiovascular mortality.
With specific reference to proteinuria in human and animal disease phenotypes, the following review explores the roles of the endothelial cell, glomerular basement membrane, and the podocyte and attempts to highlight examples of essential crosstalk within this barrier.
American Psychological Association (APA)
Menon, Madhav C.& Chuang, Peter Y.& He, Cijiang John. 2012. The Glomerular Filtration Barrier : Components and Crosstalk. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-495630
Modern Language Association (MLA)
Menon, Madhav C.…[et al.]. The Glomerular Filtration Barrier : Components and Crosstalk. International Journal of Nephrology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-495630
American Medical Association (AMA)
Menon, Madhav C.& Chuang, Peter Y.& He, Cijiang John. The Glomerular Filtration Barrier : Components and Crosstalk. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-495630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495630