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Severe Starvation-Induced Hepatocyte Autophagy as a Cause of Acute Liver Injury in Anorexia Nervosa : A Case Report
Joint Authors
Restellini, S.
Rubbia-Brandt, Laura
Spahr, Laurent
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Mild elevation of transaminase may be observed in anorexia nervosa, but acute liver injury is uncommon.
A complex programmed cell death in response to starvation, called autophagy, has been described in experimental and human studies.
Case Presentation.
A 24-year-old woman suffering from anorexia nervosa was hospitalized for severe malnutrition.
At admission, there were biological signs of acute liver injury but no electrolytic imbalance.
After having ruled out the most common causes of liver injury, the patient was carefully refed.
As liver tests remained abnormal, liver biopsy was performed.
At histology and electron microscopy, numerous signs suggestive of starvation-induced hepatocyte autophagy were found.
Discussion.
Severe starvation can be associated with acute liver injury that is slowly reversible with careful enteral nutrition.
In this clinical situation, profound hepatic glycogen depletion in association with autophagy appears as the leading cause of liver injury.
American Psychological Association (APA)
Restellini, S.& Spahr, Laurent& Rubbia-Brandt, Laura. 2013. Severe Starvation-Induced Hepatocyte Autophagy as a Cause of Acute Liver Injury in Anorexia Nervosa : A Case Report. Case Reports in Hepatology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-495647
Modern Language Association (MLA)
Restellini, S.…[et al.]. Severe Starvation-Induced Hepatocyte Autophagy as a Cause of Acute Liver Injury in Anorexia Nervosa : A Case Report. Case Reports in Hepatology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-495647
American Medical Association (AMA)
Restellini, S.& Spahr, Laurent& Rubbia-Brandt, Laura. Severe Starvation-Induced Hepatocyte Autophagy as a Cause of Acute Liver Injury in Anorexia Nervosa : A Case Report. Case Reports in Hepatology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-495647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495647