The Avian Proghrelin System
Joint Authors
McMurtry, John P.
Richards, Mark P.
Source
International Journal of Peptides
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
To understand how the proghrelin system functions in regulating growth hormone release and food intake as well as defining its pleiotropic roles in such diverse physiological processes as energy homeostasis, gastrointestinal tract function and reproduction require detailed knowledge of the structure and function of the components that comprise this system.
These include the preproghrelin gene that encodes the proghrelin precursor protein from which two peptide hormones, ghrelin and obestatin, are derived and the cognate receptors that bind proghrelin-derived peptides to mediate their physiological actions in different tissues.
Also key to the functioning of this system is the posttranslational processing of the proghrelin precursor protein and the individual peptides derived from it.
While this system has been intensively studied in a variety of animal species and humans over the last decade, there has been considerably less investigation of the avian proghrelin system which exhibits some unique differences compared to mammals.
This review summarizes what is currently known about the proghrelin system in birds and offers new insights into the nature and function of this important endocrine system.
Such information facilitates cross-species comparisons and contributes to our understanding of the evolution of the proghrelin system.
American Psychological Association (APA)
Richards, Mark P.& McMurtry, John P.. 2010. The Avian Proghrelin System. International Journal of Peptides،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-495671
Modern Language Association (MLA)
Richards, Mark P.& McMurtry, John P.. The Avian Proghrelin System. International Journal of Peptides No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-495671
American Medical Association (AMA)
Richards, Mark P.& McMurtry, John P.. The Avian Proghrelin System. International Journal of Peptides. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-495671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495671