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Clinical Efficacy of Artemether-Lumefantrine in Congolese Children with Acute Uncomplicated Falciparum Malaria in Brazzaville
Joint Authors
Basco, Leonardo K.
Tahar, Rachida
Casimiro, Prisca N.
Loumouamou, Dieudonné
Ndounga, Mathieu
Source
Malaria Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The Republic of the Congo adopted artemisinin-based combination therapies (ACTs) in 2006: artesunate-amodiaquine and artemether-lumefantrine as the first-line and second-line drugs, respectively.
The baseline efficacy of artemether-lumefantrine was evaluated between March and July 2006 in Brazzaville, the capital city of Congo.
Seventy-seven children aged between 6 months and 10 years were enrolled in a nonrandomized study.
The children were treated under supervision with 6 doses of artemether-lumefantrine and followed up for 28 days in accordance with the 2003 World Health Organization guideline.
Pretreatment (i.e., day 0) and recrudescent Plasmodium falciparum isolates between day 14 and day 28 were compared by the polymerase chain reaction to distinguish between true recrudescence and reinfection.
The overall cure rate on day 28 was 96.9% after PCR correction.
Reported adverse effects included pruritus and dizziness.
Artemether-lumefantrine was highly efficacious in Brazzaville.
American Psychological Association (APA)
Ndounga, Mathieu& Tahar, Rachida& Casimiro, Prisca N.& Loumouamou, Dieudonné& Basco, Leonardo K.. 2012. Clinical Efficacy of Artemether-Lumefantrine in Congolese Children with Acute Uncomplicated Falciparum Malaria in Brazzaville. Malaria Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-495678
Modern Language Association (MLA)
Ndounga, Mathieu…[et al.]. Clinical Efficacy of Artemether-Lumefantrine in Congolese Children with Acute Uncomplicated Falciparum Malaria in Brazzaville. Malaria Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-495678
American Medical Association (AMA)
Ndounga, Mathieu& Tahar, Rachida& Casimiro, Prisca N.& Loumouamou, Dieudonné& Basco, Leonardo K.. Clinical Efficacy of Artemether-Lumefantrine in Congolese Children with Acute Uncomplicated Falciparum Malaria in Brazzaville. Malaria Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-495678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495678