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Metformin-Associated Acute Kidney Injury and Lactic Acidosis
Joint Authors
Tejedor, Alberto
Luño, José
Rodríguez-Benítez, Patrocinio
Panizo, Nayara
Vinuesa, Soledad García
Verde, Eduardo
Arroyo, David
Goicoechea, Marian
Melero, Rosa
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
Metformin is the preferred oral antidiabetic agent for type 2 diabetes.
Lactic acidosis is described as a rare complication, usually during an acute kidney injury (AKI).
Material and Methods.
We conducted a prospective observational study of metformin-associated AKI cases during four years.
29 cases were identified.
Previous renal function, clinical data, and outcomes were recorded.
Results.
An episode of acute gastroenteritis precipitated the event in 26 cases.
Three developed a septic shock.
Three patients died, the only related factor being liver dysfunction.
More severe metabolic acidosis hyperkalemia and anemia were associated with higher probabilities of RRT requirement.
We could not find any relationship between previous renal dysfunction and the outcome of the AKI.
Conclusions.
AKI associated to an episode of volume depletion due to gastrointestinal losses is a serious complication in type 2 diabetic patients on metformin.
Previous renal dysfunction (mild-to-moderate CKD) has no influence on the severity or outcome.
American Psychological Association (APA)
Arroyo, David& Melero, Rosa& Panizo, Nayara& Goicoechea, Marian& Rodríguez-Benítez, Patrocinio& Vinuesa, Soledad García…[et al.]. 2011. Metformin-Associated Acute Kidney Injury and Lactic Acidosis. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-495701
Modern Language Association (MLA)
Arroyo, David…[et al.]. Metformin-Associated Acute Kidney Injury and Lactic Acidosis. International Journal of Nephrology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-495701
American Medical Association (AMA)
Arroyo, David& Melero, Rosa& Panizo, Nayara& Goicoechea, Marian& Rodríguez-Benítez, Patrocinio& Vinuesa, Soledad García…[et al.]. Metformin-Associated Acute Kidney Injury and Lactic Acidosis. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-495701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495701