Memantine as an Augmentation Therapy for Anxiety Disorders
Joint Authors
Siddiqui, Umar A.
Raza, Shafi
Schwartz, Thomas L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Objective.
Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety.
Memantine partially blocks N-methyl-D-aspartate (NMDA) receptors' glutamate channels located in the CNS.
This paper evaluates memantine as an augmentation therapy for treatment of anxiety.
Methods.
15 consecutive partially responding anxious patients were treated with adjunctive memantine for 10 weeks.
Memantine was dosed 5–20 mg/day.
Result.
Memantine augmentation resulted in clinically relevant reduction in anxiety symptoms when compared to baseline.
Forty percent of patients achieved remission (HAM-A ≥ 7).
Memantine improved sleep quality.
Mean dose was 14 mg/d (range 5–20 mg/d).
Typical adverse events included nausea and headache.
Conclusion.
The NMDA receptor antagonist memantine may be an effective augmentation therapy in patients with treatment-resistant anxiety.
American Psychological Association (APA)
Schwartz, Thomas L.& Siddiqui, Umar A.& Raza, Shafi. 2012. Memantine as an Augmentation Therapy for Anxiety Disorders. Case Reports in Psychiatry،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-495714
Modern Language Association (MLA)
Schwartz, Thomas L.…[et al.]. Memantine as an Augmentation Therapy for Anxiety Disorders. Case Reports in Psychiatry No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-495714
American Medical Association (AMA)
Schwartz, Thomas L.& Siddiqui, Umar A.& Raza, Shafi. Memantine as an Augmentation Therapy for Anxiety Disorders. Case Reports in Psychiatry. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-495714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495714