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Carbon Monoxide Targeting Mitochondria
Joint Authors
Queiroga, Cláudia S. F.
Almeida, Ana S.
Vieira, Helena L. A.
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mitochondria present two key roles on cellular functioning: (i) cell metabolism, being the main cellular source of energy and (ii) modulation of cell death, by mitochondrial membrane permeabilization.
Carbon monoxide (CO) is an endogenously produced gaseoustransmitter, which presents several biological functions and is involved in maintaining cell homeostasis and cytoprotection.
Herein, mitochondrion is approached as the main cellular target of carbon monoxide (CO).
In this paper, two main perspectives concerning CO modulation of mitochondrial functioning are evaluated.
First, the role of CO on cellular metabolism, in particular oxidative phosphorylation, is discussed, namely, on: cytochrome c oxidase activity, mitochondrial respiration, oxygen consumption, mitochondrial biogenesis, and general cellular energetic status.
Second, the mitochondrial pathways involved in cell death inhibition by CO are assessed, in particular the control of mitochondrial membrane permeabilization.
American Psychological Association (APA)
Queiroga, Cláudia S. F.& Almeida, Ana S.& Vieira, Helena L. A.. 2012. Carbon Monoxide Targeting Mitochondria. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-495721
Modern Language Association (MLA)
Queiroga, Cláudia S. F.…[et al.]. Carbon Monoxide Targeting Mitochondria. Biochemistry Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-495721
American Medical Association (AMA)
Queiroga, Cláudia S. F.& Almeida, Ana S.& Vieira, Helena L. A.. Carbon Monoxide Targeting Mitochondria. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-495721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495721