Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes
Joint Authors
de Haan, Judy B.
Sharma, Arpeeta
Bernatchez, Pascal N.
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiovascular complications associated with diabetes remain a significant health issue in westernized societies.
Overwhelming evidence from clinical and laboratory investigations have demonstrated that these cardiovascular complications are initiated by a dysfunctional vascular endothelium.
Indeed, endothelial dysfunction is one of the key events that occur during diabetes, leading to the acceleration of cardiovascular mortality and morbidity.
In a diabetic milieu, endothelial dysfunction occurs as a result of attenuated production of endothelial derived nitric oxide (EDNO) and augmented levels of reactive oxygen species (ROS).
Thus, in this review, we discuss novel therapeutic targets that either upregulate EDNO production or increase antioxidant enzyme capacity in an effort to limit oxidative stress and restore endothelial function.
In particular, endogenous signaling molecules that positively modulate EDNO synthesis and mimetics of endogenous antioxidant enzymes will be highlighted.
Consequently, manipulation of these unique targets, either alone or in combination, may represent a novel strategy to confer vascular protection, with the ultimate goal of improved outcomes for diabetes-associated vascular complications.
American Psychological Association (APA)
Sharma, Arpeeta& Bernatchez, Pascal N.& de Haan, Judy B.. 2011. Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-495730
Modern Language Association (MLA)
Sharma, Arpeeta…[et al.]. Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes. International Journal of Vascular Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-495730
American Medical Association (AMA)
Sharma, Arpeeta& Bernatchez, Pascal N.& de Haan, Judy B.. Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes. International Journal of Vascular Medicine. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-495730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495730