Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs
Joint Authors
Fesler, Pierre
Collart, Frédéric
Brimioulle, Serge
Kerbaul, François
Mekkaoui, Choukri
By, Youlet
Ruf, Jean
Guieu, Régis
Jammes, Yves
Gariboldi, Vlad
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Adenosine plays a role in pulmonary arterial (PA) resistance due to its vasodilator properties.
However, the behavior of adenosine plasma levels (APLs) during pulmonary embolism remains unknown.
We investigated the effects of gradual pulmonary embolism on right ventricular (RV) contractility and PA coupling and on APLs in an piglet experimental model of RV failure.
PA distal resistance by pressure-flow relationships and pulmonary vascular impedance were measured.
RV contractility was determined by the end-systolic pressure-volume relationship (Ees), PA effective elastance by the end-diastolic to end-systolic relationship (Ea), and RV-PA coupling efficiency by the Ees/Ea ratio.
APLs were measured before and during gradual pulmonary embolization.
PA embolism increased PA resistance and elastance, increased Ea from 1.08±0.15 to 5.62±0.32 mmHg/mL, decreased Ees from 1.82±0.10 to 1.20±0.23 mmHg/mL, and decreased Ees/Ea from 1.69±0.15 to 0.21±0.07.
APLs decreased from 2.7±0.26 to 1.3±0.12 μM in the systemic bed and from 4.03±0.63 to 2.51±0.58 μM in the pulmonary bed during embolism procedure.
Pulmonary embolism worsens PA hemodynamics and RV-PA coupling.
APLs were reduced, both in the systemic and in the pulmonary bed, leading then to pulmonary vasoconstriction.
American Psychological Association (APA)
Kerbaul, François& By, Youlet& Gariboldi, Vlad& Mekkaoui, Choukri& Fesler, Pierre& Collart, Frédéric…[et al.]. 2011. Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs. ISRN Cardiology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-495755
Modern Language Association (MLA)
Kerbaul, François…[et al.]. Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs. ISRN Cardiology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-495755
American Medical Association (AMA)
Kerbaul, François& By, Youlet& Gariboldi, Vlad& Mekkaoui, Choukri& Fesler, Pierre& Collart, Frédéric…[et al.]. Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs. ISRN Cardiology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-495755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495755