Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs

Joint Authors

Fesler, Pierre
Collart, Frédéric
Brimioulle, Serge
Kerbaul, François
Mekkaoui, Choukri
By, Youlet
Ruf, Jean
Guieu, Régis
Jammes, Yves
Gariboldi, Vlad

Source

ISRN Cardiology

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-04-26

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases

Abstract EN

Adenosine plays a role in pulmonary arterial (PA) resistance due to its vasodilator properties.

However, the behavior of adenosine plasma levels (APLs) during pulmonary embolism remains unknown.

We investigated the effects of gradual pulmonary embolism on right ventricular (RV) contractility and PA coupling and on APLs in an piglet experimental model of RV failure.

PA distal resistance by pressure-flow relationships and pulmonary vascular impedance were measured.

RV contractility was determined by the end-systolic pressure-volume relationship (Ees), PA effective elastance by the end-diastolic to end-systolic relationship (Ea), and RV-PA coupling efficiency by the Ees/Ea ratio.

APLs were measured before and during gradual pulmonary embolization.

PA embolism increased PA resistance and elastance, increased Ea from 1.08±0.15 to 5.62±0.32 mmHg/mL, decreased Ees from 1.82±0.10 to 1.20±0.23 mmHg/mL, and decreased Ees/Ea from 1.69±0.15 to 0.21±0.07.

APLs decreased from 2.7±0.26 to 1.3±0.12 μM in the systemic bed and from 4.03±0.63 to 2.51±0.58 μM in the pulmonary bed during embolism procedure.

Pulmonary embolism worsens PA hemodynamics and RV-PA coupling.

APLs were reduced, both in the systemic and in the pulmonary bed, leading then to pulmonary vasoconstriction.

American Psychological Association (APA)

Kerbaul, François& By, Youlet& Gariboldi, Vlad& Mekkaoui, Choukri& Fesler, Pierre& Collart, Frédéric…[et al.]. 2011. Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs. ISRN Cardiology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-495755

Modern Language Association (MLA)

Kerbaul, François…[et al.]. Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs. ISRN Cardiology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-495755

American Medical Association (AMA)

Kerbaul, François& By, Youlet& Gariboldi, Vlad& Mekkaoui, Choukri& Fesler, Pierre& Collart, Frédéric…[et al.]. Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs. ISRN Cardiology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-495755

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-495755