Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes
Joint Authors
Kosmadaki, Marita
Wu, Christina
Yaar, Mina
Gilchrest, Barbara A.
Stachur, Christina M.
Park, Hee-Young
Source
International Journal of Cell Biology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bone Morphogenetic Protein (BMP-4) was shown to down-regulate melanogenesis, in part, by decreasing the level of tyrosinase [Yaar et al.
(2006) JBC:281].
Results presented here show that BMP-4 down-regulated the protein levels of TRP-1, PKC-β, and MCI-R.
When paired cultures of human melanocytes were treated with vehicle or BMP-4 (25 ng/ml), MAPK/ERK were phosphorylated within one hour of BMP-4 treatment.
Then the activated MAPK/ERK caused an acute phosphorylation of MITF, followed by proteosome-mediated degradation of MITF, the key transcription factor for melanogenic proteins [Wu et al.
(2000) Gene & Development:14].
However, prolonged exposure of melanocytes to BMP-4 (up to 48 hours) caused a decrease in the level of MITF-M transcript.
In addition, BMP-4 decreased the intracellular level of cAMP, the key regulator of MITF expression.
These results demonstrate that BMP-4 activates MAPK/ERK signaling pathway to transiently activate MITF; however, chronic treatment of BMP-4 to melanocytes causes a down-regulation of the expression of MITF, possibly in a cAMP-dependent pathway.
American Psychological Association (APA)
Park, Hee-Young& Wu, Christina& Yaar, Mina& Stachur, Christina M.& Kosmadaki, Marita& Gilchrest, Barbara A.. 2009. Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes. International Journal of Cell Biology،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-495775
Modern Language Association (MLA)
Park, Hee-Young…[et al.]. Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes. International Journal of Cell Biology No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-495775
American Medical Association (AMA)
Park, Hee-Young& Wu, Christina& Yaar, Mina& Stachur, Christina M.& Kosmadaki, Marita& Gilchrest, Barbara A.. Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes. International Journal of Cell Biology. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-495775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495775