The Increased Type-1 and Type-2 Chemokine Levels in Children with Acute RSV Infection Alter the Development of Adaptive Immune Responses
Joint Authors
Vojvoda, Valerija
Bendelja, Krešo
Savić Mlakar, Ana
Kukuruzović, Mirela
Rabatić, Sabina
Markovinović, Leo
Jergović, Mladen
Aberle, Neda
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Severe RSV infections and frequent recurrence could be related to the altered polarization of type-2/type-1 T cells.
This increases the importance of determining distinctive chemokines and chemokine receptor profiles on memory T cells.
We analyzed systemic adaptive T cell response in the acute (n=17) and convalescent phase (n=7) of RSV-infected children, in the acute (n=11) and convalescent phase (n=6) of children with other viral respiratory infections (adenovirus and influenza virus), and in healthy children (n=18).
Expression of CCR4 and CXCR3 on effector-memory (TEM) and central-memory (TCM) T cells was compared between tested groups.
Serum concentrations of specific chemokines were determined.
High CXCL10 levels were detected in acutely infected children regardless of virus pathogen, whereas increased CCL17 production was RSV-specific.
Higher percentages of CCR4+ CD4 TEM cells in acute RSV infection were accompanied with higher percentages of CXCR3+ CD8 TEM cells, whereas the development of long-lived memory CXCR3+ CD4 and CD8 TCM cells seems to be compromised, as only children with other viral infections had higher percentages in the convalescent phase.
Presence of type-2 and type-1 adaptive antiviral immune response, together with insufficient development of long-lived type-1 T cell memory, could play an important role in RSV pathogenesis and reinfection.
American Psychological Association (APA)
Vojvoda, Valerija& Savić Mlakar, Ana& Jergović, Mladen& Kukuruzović, Mirela& Markovinović, Leo& Aberle, Neda…[et al.]. 2014. The Increased Type-1 and Type-2 Chemokine Levels in Children with Acute RSV Infection Alter the Development of Adaptive Immune Responses. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-495781
Modern Language Association (MLA)
Vojvoda, Valerija…[et al.]. The Increased Type-1 and Type-2 Chemokine Levels in Children with Acute RSV Infection Alter the Development of Adaptive Immune Responses. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-495781
American Medical Association (AMA)
Vojvoda, Valerija& Savić Mlakar, Ana& Jergović, Mladen& Kukuruzović, Mirela& Markovinović, Leo& Aberle, Neda…[et al.]. The Increased Type-1 and Type-2 Chemokine Levels in Children with Acute RSV Infection Alter the Development of Adaptive Immune Responses. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-495781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495781