Simple Use of the Suppository Type Povidone-Iodine Can Prevent Infectious Complications in Transrectal Ultrasound-Guided Prostate Biopsy

Abstract EN

Purpose.

To determine the effect of simple use of suppository povidone-iodine on infectious complications after transrectal ultrasonography-guided biopsy of the prostate.

Methods.

All 481 patients are included and received antibiotic prophylaxis.

Among them, 360 patients received povidone-iodine suppository (Gynobetadine; 200 mg) immediately prior to biopsy and 121 patients did not.

Infectious complications were classified.

To evaluate bactericidal effects, we counted bacterial colonies in the rectum, harvested from a rectal swab before insertion of the suppository and after biopsy.

Aliquots of the suspended bacterial strains were added to Mueller-Hinton agar medium for incubation.

Colony counts were determined.

Results.

Infectious complications developed in 1 case (0.3%) in the rectal preparation group (Group 1) and in 8 cases (6.6%) in the nonrectal preparation group (Group 2).

One in Group 1 had a fever without sepsis.

Two patients had sepsis and six had fever without sepsis in Group 2.

Rectal preparation was a statistically significant risk factor influencing the development of infectious complications.

In vitro experiments, the mean number of colony-forming units decreased 99.9% after the rectal povidone-iodine preparation.

Conclusions.

All through the biopsy, povidone-iodine melted into the rectum and decreased the bacterial colony count.

Simple use of povidone-iodine suppository before prostate biopsy minimizes the risk of infectious complications.