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Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, and tissue iron distribution.
Hepcidin acts by causing the degradation of its receptor, the cellular iron exporter ferroportin.
The loss of ferroportin decreases iron flow into plasma from absorptive enterocytes, from macrophages that recycle the iron of senescent erythrocytes, and from hepatocytes that store iron, thereby lowering plasma iron concentrations.
Malfunctions of the hepcidin-ferroportin axis contribute to the pathogenesis of different anemias.
Deficient production of hepcidin causes systemic iron overload in iron-loading anemias such as beta-thalassemia; whereas hepcidin excess contributes to the development of anemia in inflammatory disorders and chronic kidney disease, and may cause erythropoietin resistance.
The diagnosis of different forms of anemia will be facilitated by improved hepcidin assays, and the treatment will be enhanced by the development of hepcidin agonists and antagonists.
American Psychological Association (APA)
Nemeth, Elizabeta. 2009. Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias. Advances in Hematology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-495796
Modern Language Association (MLA)
Nemeth, Elizabeta. Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias. Advances in Hematology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-495796
American Medical Association (AMA)
Nemeth, Elizabeta. Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias. Advances in Hematology. 2009. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-495796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495796