Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity : A Cross-Sectional Study in Men
Joint Authors
Van Meerhaeghe, Alain
Serteyn, Didier
Delporte, Cédric
Franck, Thierry
Raes, Martine
Vanhamme, Luc
Moguilevsky, Nicole
Vanhaeverbeek, Michel
Roumeguère, Thierry
Van Antwerpen, Pierre
Zouaoui Boudjeltia, Karim
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized.
Previously, we showed that oxidation is not restricted to the subendothelial location.
Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells.
In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process.
We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process.
Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL.
Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels.
American Psychological Association (APA)
Zouaoui Boudjeltia, Karim& Delporte, Cédric& Van Antwerpen, Pierre& Franck, Thierry& Serteyn, Didier& Moguilevsky, Nicole…[et al.]. 2013. Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity : A Cross-Sectional Study in Men. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-495802
Modern Language Association (MLA)
Zouaoui Boudjeltia, Karim…[et al.]. Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity : A Cross-Sectional Study in Men. Mediators of Inflammation No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-495802
American Medical Association (AMA)
Zouaoui Boudjeltia, Karim& Delporte, Cédric& Van Antwerpen, Pierre& Franck, Thierry& Serteyn, Didier& Moguilevsky, Nicole…[et al.]. Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity : A Cross-Sectional Study in Men. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-495802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495802