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Susceptibility for Lupus Nephritis by Low Copy Number of the FCGR3B Gene Is Linked to Increased Levels of Pathogenic Autoantibodies
Joint Authors
Rischmueller, Maureen
Lester, Susan E.
Becker-Merok, Andrea
Nossent, Johannes C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Low copy number (CN) of the FCGR3B gene reduces FCGR3B membrane expression on neutrophils and results in clearance of a smaller amount of immune complex.
We investigated FCGR3B CN in relation to the clinical phenotype in a Caucasian SLE cohort (n=107).
FCGR3B CN was determined by three different qPCR parameter estimations (Ct−, Cy0, and cpD1) and confirmed by the FCGR2C/FCGR2A paralog ratio test.
Clinical and serological data were then analyzed for their association with FCGR3B CN.
Low FCGR3B CN (<2) was more frequent in SLE patients than in healthy controls (n=162) (20% versus 6%, OR 4.15, P=0.003) and associated with higher disease activity scores (SLEDAI 10.4 versus 6.1, P=0.03), lupus nephritis (LN) (25 versus 5%, P=0.03), and increased levels of antibodies against dsDNA (81 versus 37 IU, P=0.03), C1q (22 versus 6 IU, P=0.003), and ribosomal P (10 versus 5 IU, P=0.01).
No such associations were seen with antibodies against extractable nuclear antigens or high FCGR3B CN (>2).
In multivariate analyses, LN was independently associated with anti-C1q-Ab levels (P=0.03) and low FCGR3B CN (P=0.09).
We conclude that the susceptibility for LN in patients with low FCGR3B CN is linked to increased levels of pathogenic autoantibodies.
American Psychological Association (APA)
Nossent, Johannes C.& Becker-Merok, Andrea& Rischmueller, Maureen& Lester, Susan E.. 2013. Susceptibility for Lupus Nephritis by Low Copy Number of the FCGR3B Gene Is Linked to Increased Levels of Pathogenic Autoantibodies. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-495808
Modern Language Association (MLA)
Nossent, Johannes C.…[et al.]. Susceptibility for Lupus Nephritis by Low Copy Number of the FCGR3B Gene Is Linked to Increased Levels of Pathogenic Autoantibodies. Autoimmune Diseases No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-495808
American Medical Association (AMA)
Nossent, Johannes C.& Becker-Merok, Andrea& Rischmueller, Maureen& Lester, Susan E.. Susceptibility for Lupus Nephritis by Low Copy Number of the FCGR3B Gene Is Linked to Increased Levels of Pathogenic Autoantibodies. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-495808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495808