Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC)‎ for Oral Drug Delivery

Joint Authors

Fangueiro, Joana F.
Santana, Maria Helena A.
Macedo, Ana Sofia
Souto, Eliana B.
Andreani, Tatiana
Severino, Patrícia
Silva, Amélia M.

Source

Journal of Drug Delivery

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-11-24

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients.

These have been exploited for many features in the field of pharmaceutical technology.

Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence time.

In addition, lipid nanoparticles may also protect the loaded drugs from chemical and enzymatic degradation and gradually release drug molecules from the lipid matrix into blood, resulting in improved therapeutic profiles compared to free drug.

Therefore, due to their physiological and biodegradable properties, lipid molecules may decrease adverse side effects and chronic toxicity of the drug-delivery systems when compared to other of polymeric nature.

This paper highlights the importance of lipid nanoparticles to modify the release profile and the pharmacokinetic parameters of drugs when administrated through oral route.

American Psychological Association (APA)

Severino, Patrícia& Andreani, Tatiana& Macedo, Ana Sofia& Fangueiro, Joana F.& Santana, Maria Helena A.& Silva, Amélia M.…[et al.]. 2011. Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495817

Modern Language Association (MLA)

Severino, Patrícia…[et al.]. Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. Journal of Drug Delivery No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-495817

American Medical Association (AMA)

Severino, Patrícia& Andreani, Tatiana& Macedo, Ana Sofia& Fangueiro, Joana F.& Santana, Maria Helena A.& Silva, Amélia M.…[et al.]. Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. Journal of Drug Delivery. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495817

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-495817