Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival
Joint Authors
Kilvaer, Thomas Karsten
Bremnes, Roy Martin
Busund, Lill-Tove
Sorbye, Sveinung W.
Valkov, Andrej
Smeland, Eivind
Donnem, Tom
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Optimal treatment of nongastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) is resection with wide margins.
This study investigates the prognostic impact of the angiogenesis-associated platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in non-GIST STS patients with wide and nonwide resection margins.
Method.
Tumor samples and clinical data from 249 patients with non-GIST STS were obtained, and tissue microarrays were constructed for each specimen.
Immunohistochemistry was used to evaluate the expression of PDGF-A, -B, -C, and -D and PDGFR-α and -β.
Results.
In the multivariate analysis of patients with wide resection margins, high expression of PDGF-B (P=.013, HR = 2.954, and 95% CI = 1.255–6.956) and the coexpression of PDGF-B and PDGFR-α (overall; P=.016, high-low/low-high; P=.051, HR = 2.678, 95% CI = 0.996–7.200, high/high; P=.004, HR = 3.930, 95% CI = 1.542–10.015) were independent negative prognostic markers for disease-specific survival.
Conclusion.
PDGF-B and the coexpression of PDGF-B and PDGFR-α are strong and independent prognostic factors in non-GIST STSs with wide resection margins.
American Psychological Association (APA)
Kilvaer, Thomas Karsten& Valkov, Andrej& Sorbye, Sveinung W.& Donnem, Tom& Smeland, Eivind& Bremnes, Roy Martin…[et al.]. 2011. Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival. Sarcoma،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-495845
Modern Language Association (MLA)
Kilvaer, Thomas Karsten…[et al.]. Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival. Sarcoma No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-495845
American Medical Association (AMA)
Kilvaer, Thomas Karsten& Valkov, Andrej& Sorbye, Sveinung W.& Donnem, Tom& Smeland, Eivind& Bremnes, Roy Martin…[et al.]. Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival. Sarcoma. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-495845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495845