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The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment
Joint Authors
Huang, Jian
Zhou, Ye
Xiang, Yi
Gong, Wanghua
Bian, Xiuwu
Chen, Keqiang
Yoshimura, Teizo
Wang, Ji Ming
Zhou, Jiamin
Yao, Xiaohong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-33, 33 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
33
Main Subjects
Abstract EN
Chemoattractant receptors are a family of seven transmembrane G protein coupled receptors (GPCRs) initially found to mediate the chemotaxis and activation of immune cells.
During the past decades, the functions of these GPCRs have been discovered to not only regulate leukocyte trafficking and promote immune responses, but also play important roles in homeostasis, development, angiogenesis, and tumor progression.
Accumulating evidence indicates that chemoattractant GPCRs and their ligands promote the progression of malignant tumors based on their capacity to orchestrate the infiltration of the tumor microenvironment by immune cells, endothelial cells, fibroblasts, and mesenchymal cells.
This facilitates the interaction of tumor cells with host cells, tumor cells with tumor cells, and host cells with host cells to provide a basis for the expansion of established tumors and development of distant metastasis.
In addition, many malignant tumors of the nonhematopoietic origin express multiple chemoattractant GPCRs that increase the invasiveness and metastasis of tumor cells.
Therefore, GPCRs and their ligands constitute targets for the development of novel antitumor therapeutics.
American Psychological Association (APA)
Zhou, Jiamin& Xiang, Yi& Yoshimura, Teizo& Chen, Keqiang& Gong, Wanghua& Huang, Jian…[et al.]. 2014. The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment. BioMed Research International،Vol. 2014, no. 2014, pp.1-33.
https://search.emarefa.net/detail/BIM-495852
Modern Language Association (MLA)
Zhou, Jiamin…[et al.]. The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment. BioMed Research International No. 2014 (2014), pp.1-33.
https://search.emarefa.net/detail/BIM-495852
American Medical Association (AMA)
Zhou, Jiamin& Xiang, Yi& Yoshimura, Teizo& Chen, Keqiang& Gong, Wanghua& Huang, Jian…[et al.]. The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-33.
https://search.emarefa.net/detail/BIM-495852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495852