TRC120038, a Novel Dual AT1ETA Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats
Joint Authors
Chauthaiwale, Vijay
Mandhare, Appaji
Mohanan, Anookh
Gupta, Ram
Gupta, Ramesh C.
Jagtap, Vikrant
Dutt, Chaitanya
Dubey, Amita
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In hypertensive subjects, angiotensin II and endothelin participate in a manner involving closely interwoven pathways in increasing blood pressure (BP) and inducing end organ damage.
The primary objective of this study was to determine the effect of TRC120038, a novel dual AT1/ETA receptor blocker on BP, in obese Zucker spontaneously hypertensive fatty rats (ob-ZSF1), an animal model of moderate hypertension, diabetes with progressive renal and cardiac dysfunction.
Ob-ZSF1 rats loaded with 0.5% salt were treated with TRC120038 (11.8 mg/kg bid.) or candesartan cilexetil (0.3 mg/kg od.) or vehicle control.
Blood pressure (by radio-telemetry) and renal functional markers were monitored throughout the study.
Cardiac function was assessed terminally by pressure volume catheter.
Markers for renal dysfunction were measured and changes were evaluated histopathologically.
TRC120038 showed greater fall in both systolic and diastolic BP in comparison to candesartan at its maximum antihypertensive dose.
TRC120038 also reduced the severity of renal dysfunction and preserved cardiac function in ob-ZSF1 rat.
American Psychological Association (APA)
Mohanan, Anookh& Gupta, Ram& Dubey, Amita& Jagtap, Vikrant& Mandhare, Appaji& Gupta, Ramesh C.…[et al.]. 2011. TRC120038, a Novel Dual AT1ETA Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-495862
Modern Language Association (MLA)
Mohanan, Anookh…[et al.]. TRC120038, a Novel Dual AT1ETA Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats. International Journal of Hypertension No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-495862
American Medical Association (AMA)
Mohanan, Anookh& Gupta, Ram& Dubey, Amita& Jagtap, Vikrant& Mandhare, Appaji& Gupta, Ramesh C.…[et al.]. TRC120038, a Novel Dual AT1ETA Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-495862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495862