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Microwave-Assisted Solution Phase Synthesis of Novel 2-{4-[2-(N-Methyl-2-pyridylamino)ethoxy]phenyl}-5-Substituted 1,3,4-Oxadiazole Library
Joint Authors
Nagashima, Izuru
Gaonkar, Santosh L.
Shimizu, Hiroki
Source
Organic Chemistry International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A new series of 2-{4-[2-(N-methyl-2-pyridylamino)ethoxy]phenyl}-5-substituted 1,3,4-oxadiazoles were synthesized by the oxidative cyclization of hydrazones derived from 4-[2-(methylpyridin-2-ylamino)ethoxy]benzaldehyde and aryl hydrazines using chloramine-T as an efficient catalyst.
All steps were assisted by microwave irradiation.
Microwave enables all these reactions to be simple, rapid, high yielding, and avoid chromatograph purification and led environmentally benign total synthesis of focused oxadiazole library.
All the synthesized compounds were isolated in good yield and characterized by 1H NMR, 13C NMR, and elemental analyses.
The title compounds represent a novel class of biologically active heterocycles.
American Psychological Association (APA)
Gaonkar, Santosh L.& Nagashima, Izuru& Shimizu, Hiroki. 2012. Microwave-Assisted Solution Phase Synthesis of Novel 2-{4-[2-(N-Methyl-2-pyridylamino)ethoxy]phenyl}-5-Substituted 1,3,4-Oxadiazole Library. Organic Chemistry International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-495897
Modern Language Association (MLA)
Gaonkar, Santosh L.…[et al.]. Microwave-Assisted Solution Phase Synthesis of Novel 2-{4-[2-(N-Methyl-2-pyridylamino)ethoxy]phenyl}-5-Substituted 1,3,4-Oxadiazole Library. Organic Chemistry International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-495897
American Medical Association (AMA)
Gaonkar, Santosh L.& Nagashima, Izuru& Shimizu, Hiroki. Microwave-Assisted Solution Phase Synthesis of Novel 2-{4-[2-(N-Methyl-2-pyridylamino)ethoxy]phenyl}-5-Substituted 1,3,4-Oxadiazole Library. Organic Chemistry International. 2012. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-495897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495897