Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals
Joint Authors
Khazaei, Sara
Houshmand, Behzad
Alijani, Sara
Hajilooi, Mehrdad
Kdkhodazadeh, Mahdi
Gholami, Leila
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Our aim in this paper was to investigate the possible genetic association between three Ser563Asn, Leu125Val and Arg670Gly polymorphisms of the PECAM-1 gene and periodontitis.
Methods.
Genomic DNA was isolated from whole blood of 105 periodontal patient (52 with chronic periodontitis and 53 with aggressive periodontitis) and 101 healthy individuals.
Samples were genotyped and analyzed for the three single-nucleotide polymorphisms (SNPs) of PECAM-1 using polymerase chain reaction with sequence-specific primers (PCR-SSPs).
Results.
A statistically significant difference was found between the genotypic distribution of the Ser563Asn polymorphism in patients with periodontitis compared to controls (P=0.02).
But there were no statistically significant difference between the allele frequencies in the different groups (P=0.05).
The other two polymorphisms did not show a statistically significant difference in their allele and genotype frequencies between the groups.
There was no statistically significant difference found for any of the polymorphisms allele and genotype distribution in aggressive and chronic periodontitis either.
Conclusions.
No significant association was found between the polymorphism tested and the subgroups of periodontitis, further research is still necessary to determine whether this polymorphism can be used as a genetic marker of periodontitis.
American Psychological Association (APA)
Kdkhodazadeh, Mahdi& Hajilooi, Mehrdad& Houshmand, Behzad& Khazaei, Sara& Gholami, Leila& Alijani, Sara. 2012. Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals. ISRN Dentistry،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-495901
Modern Language Association (MLA)
Kdkhodazadeh, Mahdi…[et al.]. Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals. ISRN Dentistry No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-495901
American Medical Association (AMA)
Kdkhodazadeh, Mahdi& Hajilooi, Mehrdad& Houshmand, Behzad& Khazaei, Sara& Gholami, Leila& Alijani, Sara. Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals. ISRN Dentistry. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-495901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495901