Chondroprotective Activity of Murraya exotica through Inhibiting β-Catenin Signaling Pathway
Joint Authors
Wu, Longhuo
Liu, Haiqing
Hu, Haibo
Li, Jialin
Li, Linfu
Zhang, Rui
Huang, Hao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Osteoarthritis (OA) is a degenerative joint disease that affects millions of people.
Currently, there is no effective drug treatment for it.
The purpose of this study is to investigate the chondroprotective effects of Murraya exotica (L.) on OA.
The rat OA models were duplicated to prepare for separating OA chondrocytes, synovial fluid (SF), and serum containing M.
exotica (50 mg/kg, 100 mg/kg, and 200 mg/kg), M.
exotica showed the activity of decreasing the contents of TNF-α and IL-1β in SF and the chondrocyte apoptosis in a dose-dependent manner.
To investigate the probable mechanism, quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were used to determine gene expression and protein profiles, respectively.
The results reveal that M.
exotica can downregulate mRNA and protein expressions of β-catenin and COX-2 and reporter activity significantly.
Conclusively, M.
exotica exhibits antiapoptotic chondroprotective activity probably through inhibiting β-catenin signaling.
American Psychological Association (APA)
Wu, Longhuo& Liu, Haiqing& Zhang, Rui& Li, Linfu& Li, Jialin& Hu, Haibo…[et al.]. 2013. Chondroprotective Activity of Murraya exotica through Inhibiting β-Catenin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-495922
Modern Language Association (MLA)
Wu, Longhuo…[et al.]. Chondroprotective Activity of Murraya exotica through Inhibiting β-Catenin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-495922
American Medical Association (AMA)
Wu, Longhuo& Liu, Haiqing& Zhang, Rui& Li, Linfu& Li, Jialin& Hu, Haibo…[et al.]. Chondroprotective Activity of Murraya exotica through Inhibiting β-Catenin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-495922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495922