Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats
Joint Authors
Wu, Jin-Bin
Ho, Hui-Ya
Lin, Wen-Chuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Flemingia macrophylla (Leguminosae), a native plant of Taiwan, is used as folk medicine.
An in vitro study showed that a 75% ethanolic extract of F.
macrophylla (FME) inhibited osteoclast differentiation of cultured rat bone marrow cells, and the active component, lespedezaflavanone A (LDF-A), was isolated.
It was found that oral administration of FME for 13 weeks suppressed bone loss in ovariectomized rats, an experimental model of osteoporosis.
In addition, FME decreased urinary deoxypyridinoline concentrations but did not inhibit serum alkaline phosphatase activities, indicating that it ameliorated bone loss via inhibition of bone resorption.
These results suggest that FME may represent a useful remedy for the treatment of bone resorption diseases, such as osteoporosis.
In addition, LDF-A could be used as a marker compound to control the quality of FME.
American Psychological Association (APA)
Ho, Hui-Ya& Wu, Jin-Bin& Lin, Wen-Chuan. 2011. Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-495928
Modern Language Association (MLA)
Ho, Hui-Ya…[et al.]. Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-495928
American Medical Association (AMA)
Ho, Hui-Ya& Wu, Jin-Bin& Lin, Wen-Chuan. Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-495928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495928
